Name:Luminespib (NVP-AUY922)
Synonyms:AUY-922, VER-52296
CAS Number:747412-49-3
Formula:C26H31N3O5
M.w.:465.54
DMSO (mg/mL)Max Solubility:93
DMSO (mM)Max Solubility:199.77
Form:free base
SMILES:CCNC(=O)C1=NOC(=C1C2=CC=C(CN3CCOCC3)C=C2)C4=CC(=C(O)C=C4O)C(C)C
ALogP:4.069
Target:Apoptosis related,Autophagy,HSP (HSP90),IGF-1R
Pathway:Cytoskeletal Signaling
Information:Luminespib (AUY-922, NVP-AUY922, VER-52296) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1Rβ protein and results in growth inhibition, autophagy and apoptosis. Phase 2.
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