Name:Crizotinib (PF-02341066)
Synonyms:PF-02341066
CAS Number:877399-52-5
Formula:C21H22Cl2FN5O
M.w.:450.34
DMSO (mg/mL)Max Solubility:9
DMSO (mM)Max Solubility:19.98
Form:free base
SMILES:CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F
ALogP:3.693
Target:ALK,Autophagy,c-Met,ROS1
Pathway:Protein Tyrosine Kinase
Information:Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
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