Name:Harmine
Synonyms:Telepathine
CAS Number:442-51-3
Formula:C13H12N2O
M.w.:212.25
DMSO (mg/mL)Max Solubility:42
DMSO (mM)Max Solubility:197.88
Form:free base
SMILES:COC1=CC2=C(C=C1)C3=CC=NC(=C3[NH]2)C
ALogP:2.438
Target:MAO,PPAR
Pathway:Metabolism
Information:Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
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