生物活性：N-Nitrosodiethylamine-d4 is the deuterium labeled N-Nitrosodiethylamine[1]. N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
N-Nitrosodiethylamine-d4 相关抗体:
Ctip2 Antibody
Rb Antibody
Phospho-Rb (Ser807) Antibody
RPA32 Antibody (YA679)
CDT1 Antibody
DNA-PKcs/PRKDC Antibody
Hes1 Antibody
JunB Antibody
LIN28A Antibody
Lin28B Antibody
MCM2 Antibody
Nanog Antibody
Nucleolin Antibody
PCNA Antibody
PDX1 Antibody
RbBP5 Antibody
S100A4 Antibody
SP1 Antibody
BRCA1 Antibody (YA819)
Argonaute 2 Antibody
BRCA1 Antibody
Elongation Factor 1A1 Antibody
KAP1 Antibody
MCM2 Antibody (YA705)
MLH1 Antibody (YA703)
RNA Polymerase II Subunit B1 Antibody
RPA70 Antibody (YA678)
SP7/Osterix Antibody
DNA PKcs Antibody (YA957)
DNA PKcs Antibody (YA959)
分子量：106.16
Formula：C4H6D4N2O
CAS 号：1346603-41-5
非标记 CAS：55-18-5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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