生物活性：Aflatoxin G1-13C17 is the 13C labeled Aflatoxin G1 (HY-N6697)[1]. Aflatoxin G1 is an orally active aflatoxin found in the molds Aspergillus flavus and Aspergillus parasiticus. Aflatoxin G1 is a toxic and carcinogenic mycotoxin found in rice, pepper, and other food crops. Aflatoxin G1 induces DNA damage and apoptosis in alveolar type II cells via the MAPK signaling pathway. Aflatoxin G1 upregulates TNF-α, triggering chronic lung inflammation associated with preneoplastic induction[2][3][4].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：345.15
Formula：13C17H12O7
CAS 号：1217444-07-9
非标记 CAS：1165-39-5
中文名称：黄曲霉毒素G1-13C17
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (548 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220.
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[2]. Shen H,et al. Aflatoxin G1-induced oxidative stress causes DNA damage and triggers apoptosis through MAPK signaling pathway in A549 cells. Food Chem Toxicol. 2013 Dec;62:661-9.
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[3]. Shao P, et al. Aflatoxin G1 induced TNF-α-dependent lung inflammation to enhance DNA damage in alveolar epithelial cells. J Cell Physiol. 2019 Jun;234(6):9194-9206.
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[4]. Liu C, et al. Oral administration of aflatoxin G₁ induces chronic alveolar inflammation associated with lung tumorigenesis. Toxicol Lett. 2015 Feb 3;232(3):547-56.
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