瑞禧生物货号：Ruixi-B595838
化学名称：BL 918
同义名称：(αR)-α-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-benzeneacetamide
CAS号：2101517-69-3
分子式：C₂₃H₁₅F₈N₃OS
分子量：533.44
产品类别：Standards; Enzyme Activators and Inhibitors;
产品应用：BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.
参考文献：Ouyang, Liang., et al.: J. Med. Chem., 61, 2776 (2018),
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