DSPE-PEG-Maleimide, DSPE-PEG-MAL
作者:DSPE-PEG-Maleimide, DSPE-PEG-MAL 发布时间:2022-08-01 09:05:19
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DSPE-PEG-Maleimide,
DSPE-PEG-MAL
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene
glycol)]
Synonym: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene
glycol maleimide, Maleimide PEG DSPE.
Product
Structure:
Product
Specifications:
l Catalog
Numbers:PS2-MDE-1K,2K,3K,5K,10K.
l Appearance: White
to off-white or yellowish-white solid.
l Solubility: >10
mg/mL in hot water, chloroform, DCM, methanol.
l Stability: 1 Years at-20°C, Desiccate.
l CAS
Number: 474922-22-0.
l Molecular
Weight(PEG):1K,2K,3.4K,5K,10K.
l Reactive
group: Maleimide (-MAL).
l Reactive
to: Sulfhydryl (-SH).
l Purity: 95%.
Description:
DSPE PEG Maleimide is one of
ruixibio reactive phospholipid PEG derivatives that can react with sulfhydryl
groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is an 18 carbon
phospholipid that is highly hydrophobic. PEG backbone, on the other hand,
offers good hydrophilicity and water solubility. Maleimide functionalized DSPE
PEG has excellent reactivity towards sulfhydryl/thiol groups. Reaction between
Maleimide and thiol group proceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive
phospholipids to conjugate antibodies, peptides or other ligands to the surface
of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer
blood circulation time and higher stability for encapsulated drugs. ruixibio has
developed a comprehensive collection of thiol reactive maleimide phospholipid
PEG products that have high purity, various molecular weights and excellent
chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic
properties and offer superior advantages for small and large molecule drug
formulation and delivery.
Handling
and Use:
DSPE
PEG Maleimide undergoes hydrolysis at elevated temperature and
moisture. Maleimide PEG should always be kept in low temperature in dry
condition. Prepare fresh solution right before use. Avoid frequent thaw and
freezing. For more information about using this product, .
Related
Products:
DSPE-PEG-NH2,
DSPE-PEG-COOH
DSPE-PEG-NHS
,DSPE-PEG-FA
DSPE-PEG-SH,DSPE-PEG-OPSS
References:
l Afatinib-loaded
Immunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting the
Epidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer------ International
Journal of Pharmaceutics(IF=3.862)
l Layer-by-Layer
Heparinization of the Cell Surface by Using Heparin-Binding Peptide
Functionalized Human Serum Albumin------ Materials(IF=2.467)
l Lifetime-engineered
NIR-II nanoparticles unlock multiplexed in vivo imaging------ Nature
Nanotechnology(IF=37.49)
l Multifunctional
Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving
Payload Stability and Regulating the Transcytosis Pathway------Acs applied materials&interfaces(IF=8.097)
l Biomimetic
virus-like and charge reversible nanoparticles to sequentially overcome mucus
and epithelial barriers for oral insulin delivery Acs applied materials&interfaces(IF=8.097)
l Enhanced
legumain-recognition and NIR controlled released of cisplatin-indocyanine
nanosphere against gastric carcinoma------ European
Journal of Pharmacology(IF=3.04)
This
product is for research use only and is not intended for use in humans or for
diagnostic use.