Name:Bardoxolone Methyl
Synonyms:RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me
CAS Number:218600-53-4
Formula:C32H43NO4
M.w.:505.69
DMSO (mg/mL)Max Solubility:21
DMSO (mM)Max Solubility:41.53
Form:free base
SMILES:COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2
ALogP:5.798
Target:Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2
Pathway:NF-κB
Information:Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.
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