Name:LY2811376
Synonyms:N/A
CAS Number:1194044-20-6
Formula:C15H14F2N4S
M.w.:320.36
DMSO (mg/mL)Max Solubility:16
DMSO (mM)Max Solubility:49.94
Form:free base
SMILES:CC1(CCSC(=N1)N)C2=CC(=C(F)C=C2F)C3=CN=CN=C3
ALogP:2.478
Target:BACE,Beta Amyloid
Pathway:Proteases
Information:LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
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