Name:SNS-032 (BMS-387032)
Synonyms:N/A
CAS Number:345627-80-7
Formula:C17H24N4O2S2
M.w.:380.53
DMSO (mg/mL)Max Solubility:76
DMSO (mM)Max Solubility:199.72
Form:free base
SMILES:CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1
ALogP:2.07
Target:Apoptosis related,CDK
Pathway:Cell Cycle
Information:SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis.
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