Name:GSK690693
Synonyms:N/A
CAS Number:937174-76-0
Formula:C21H27N7O3
M.w.:425.48
DMSO (mg/mL)Max Solubility:39
DMSO (mM)Max Solubility:91.66
Form:free base
SMILES:CC[N]1C(=NC2=C1C(=CN=C2C#CC(C)(C)O)OCC3CCCNC3)C4=NON=C4N
ALogP:1.839
Target:Akt,AMPK,Autophagy,DAPK,PKA,PKC,STING,ULK
Pathway:PI3K/Akt/mTOR
Information:GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
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