Name:Bortezomib (PS-341)
Synonyms:Velcade, LDP-341, MLM341, NSC 681239,PS-341
CAS Number:179324-69-7
Formula:C19H25BN4O4
M.w.:384.24
DMSO (mg/mL)Max Solubility:76
DMSO (mM)Max Solubility:197.79
Form:Free Base
SMILES:CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O
ALogP:2.183
Target:Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome
Pathway:Proteases
Information:Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
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