Name:Eflornithine (MDL-71782) hydrochloride hydrate
Synonyms:Difluoromethylornithine hydrochloride hydrate, DFMO hydrochloride hydrate, RMI-71782 hydrochloride hydrate, α-difluoromethylornithine hydrochloride hydrate
CAS Number:96020-91-6
Formula:C6H12F2N2O2.HCl.H2O
M.w.:236.64
DMSO (mg/mL)Max Solubility:<1
DMSO (mM)Max Solubility:N/A
Form:hydrochloride hydrate
SMILES:O.Cl.NCCCC(N)(C(F)F)C(O)=O
ALogP:-3.046
Target:Decarboxylase
Pathway:Metabolism
Information:Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
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