Name:Selitrectinib (LOXO-195)
Synonyms:BAY 2731954
CAS Number:2097002-61-2
Formula:C20H21FN6O
M.w.:380.42
DMSO (mg/mL)Max Solubility:38
DMSO (mM)Max Solubility:99.89
Form:Free base
SMILES:CC1CCC2=C(C=C(F)C=N2)C3CCCN3C4=NC5=C(C=N[N]5C=C4)C(=O)N1
ALogP:2.056
Target:Trk receptor
Pathway:Protein Tyrosine Kinase
Information:Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested.
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