Name:Phorbol 12-myristate 13-acetate (PMA)
Synonyms:12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate
CAS Number:16561-29-8
Formula:C36H56O8
M.w.:616.83
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:162.12
Form:Free base
SMILES:CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C2C=C(C)C3=O)C4C(C)(C)C14OC(C)=O
ALogP:5.923
Target:PKC,S1P Receptor
Pathway:Cytoskeletal Signaling
Information:Phorbol 12-myristate 13-acetate (PMA,12-O-Tetradecanoylphorbol-13-acetate, TPA, Phorbol myristate acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.
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