Name:Olodanrigan (EMA401)
Synonyms:PD-126055, (S) PD-126055
CAS Number:1316755-16-4
Formula:C32H29NO5
M.w.:507.58
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:197.01
Form:Free Base
SMILES:COC1=C(OCC2=CC=CC=C2)C3=C(CN(C(C3)C(O)=O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C=C1
ALogP:5.599
Target:Angiotensin Receptor
Pathway:GPCR & G Protein
Information:Olodanrigan (EMA401, PD-126055, (S) PD-126055) is a highly selective, orally active, peripherally restricted antagonist of angiotensin II type 2 receptor (AT2R). Olodanrigan (EMA401) analgesic action appears to involve the inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
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