Name:Farudodstat
Synonyms:LAS 186323,ASLAN003
CAS Number:1035688-66-4
Formula:C19H14F2N2O3
M.w.:356.32
DMSO (mg/mL)Max Solubility:71
DMSO (mM)Max Solubility:199.26
Form:Free Base
SMILES:COC1=CC=CC(=C1)C2=CC(=C(NC3=NC=CC=C3C(O)=O)C(=C2)F)F
ALogP:4.311
Target:AP-1,Apoptosis related,Dehydrogenase
Pathway:Metabolism
Information:Farudodstat(LAS 186323,ASLAN003) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.
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