Name:Dabigatran etexilate mesylate
Synonyms:Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate
CAS Number:872728-81-9
Formula:C35H45N7O8S
M.w.:723.84
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:138.15
Form:Mesylate
SMILES:CCCCCCOC(=O)NC(=N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C4=CC=CC=N4)[N]2C)C=C1.C[S](O)(=O)=O
ALogP:5.337
Target:Thrombin
Pathway:Proteases
Information:Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4.5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM.
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