Name:Crizotinib hydrochloride
Synonyms:Xalkori, PF-02341066 hydrochloride
CAS Number:1415560-69-8
Formula:C21H23Cl3FN5O
M.w.:486.8
DMSO (mg/mL)Max Solubility:97
DMSO (mM)Max Solubility:199.26
Form:Hydrochloride
SMILES:Cl.CC(OC1=C(N)N=CC(=C1)C2=C[N](N=C2)C3CCNCC3)C4=C(Cl)C=CC(=C4Cl)F
ALogP:4.075
Target:ALK,Autophagy,c-Met,ROS1
Pathway:Protein Tyrosine Kinase
Information:Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
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