Name:Homoharringtonine (CGX-635)
Synonyms:Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633
CAS Number:26833-87-4
Formula:C29H39NO9
M.w.:545.62
DMSO (mg/mL)Max Solubility:10
DMSO (mM)Max Solubility:18.33
Form:free Base
SMILES:COC(=O)CC(O)(CCCC(C)(C)O)C(=O)OC1C2C3=CC4=C(OCO4)C=C3CCN5CCCC25C=C1OC
ALogP:2.418
Target:STAT
Pathway:JAK/STAT
Information:Homoharringtonine (CGX-635, Omacetaxine mepesuccinate, HHT, Myelostat, NSC 141633), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.
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