Name:Cobimetinib (GDC-0973)
Synonyms:RG7420,XL518
CAS Number:934660-93-2
Formula:C21H21F3IN3O2
M.w.:531.31
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:188.21
Form:free base
SMILES:OC1(CN(C1)C(=O)C2=C(NC3=CC=C(I)C=C3F)C(=C(F)C=C2)F)C4CCCCN4
ALogP:3.701
Target:Apoptosis related,MEK
Pathway:MAPK
Information:Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.
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