Name:Xanthohumol
Synonyms:N/A
CAS Number:6754-58-1
Formula:C21H22O5
M.w.:354.4
DMSO (mg/mL)Max Solubility:70
DMSO (mM)Max Solubility:197.52
Form:free base
SMILES:COC1=C(C(=C(CC=C(C)C)C(=C1)O)O)C(=O)\C=C\C2=CC=C(O)C=C2
ALogP:4.816
Target:Acyltransferase,Apoptosis related,CMV,COX
Pathway:Metabolism
Information:Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses. Xanthohumol induces growth inhibition and apoptosis in cancer cells. Phase 1.
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