Name:Apilimod (STA-5326)
Synonyms:STA-5326
CAS Number:541550-19-0
Formula:C23H26N6O2
M.w.:418.49
DMSO (mg/mL)Max Solubility:84
DMSO (mM)Max Solubility:200.72
Form:Free Base
SMILES:CC1=CC=CC(=C1)\C=N\NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
ALogP:4.485
Target:Interleukins,PIKfyve
Pathway:PI3K/Akt/mTOR
Information:Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
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