Name:Fenretinide (NSC 374551)
Synonyms:4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016
CAS Number:65646-68-6
Formula:C26H33NO2
M.w.:391.55
DMSO (mg/mL)Max Solubility:78
DMSO (mM)Max Solubility:199.21
Form:free base
SMILES:CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)NC2=CC=C(O)C=C2)C(C)(C)CCC1
ALogP:6.463
Target:Retinoid Receptor
Pathway:Metabolism
Information:Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
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