Name:Nordihydroguaiaretic acid (NDGA)
Synonyms:N/A
CAS Number:500-38-9
Formula:C18H22O4
M.w.:302.36
DMSO (mg/mL)Max Solubility:60
DMSO (mM)Max Solubility:198.44
Form:free base
SMILES:CC(CC1=CC=C(O)C(=C1)O)C(C)CC2=CC=C(O)C(=C2)O
ALogP:4.708
Target:Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HER2,IGF-1R,Lipoxygenase
Pathway:Metabolism
Information:Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.
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