Name:Fedratinib (TG101348)
Synonyms:SAR302503
CAS Number:936091-26-8
Formula:C27H36N6O3S
M.w.:524.68
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:190.59
Form:free base
SMILES:CC1=C(NC2=CC=CC(=C2)[S](=O)(=O)NC(C)(C)C)N=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=C1
ALogP:5.123
Target:Apoptosis related,c-RET,FLT3,JAK
Pathway:JAK/STAT
Information:Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.
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