Name:Flavopiridol (L86-8275) HCl
Synonyms:NSC 649890, Alvocidib, HMR-1275, DSP-2033
CAS Number:131740-09-5
Formula:C21H20ClNO5.HCl
M.w.:438.3
DMSO (mg/mL)Max Solubility:88
DMSO (mM)Max Solubility:200.78
Form:Hydrochloride
SMILES:Cl.CN1CCC(C(O)C1)C2=C3OC(=CC(=O)C3=C(O)C=C2O)C4=C(Cl)C=CC=C4
ALogP:3.49
Target:Autophagy,CDK,HIV
Pathway:Cell Cycle
Information:Flavopiridol HCl (L86-8275, NSC 649890, Alvocidib, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.
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