Name:Rabusertib (LY2603618)
Synonyms:IC-83
CAS Number:911222-45-2
Formula:C18H22BrN5O3
M.w.:436.3
DMSO (mg/mL)Max Solubility:13
DMSO (mM)Max Solubility:29.8
Form:free base
SMILES:CC1=NC=C(NC(=O)NC2=C(OCC3CNCCO3)C=C(C)C(=C2)Br)N=C1
ALogP:1.58
Target:Apoptosis related,Autophagy,Chk
Pathway:Cell Cycle
Information:Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.
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