Name:SP600125
Synonyms:Nsc75890
CAS Number:129-56-6
Formula:C14H8N2O
M.w.:220.23
DMSO (mg/mL)Max Solubility:44
DMSO (mM)Max Solubility:199.79
Form:free base
SMILES:O=C1C2=C(C=CC=C2)C3=N[NH]C4=CC=CC1=C34
ALogP:2.994
Target:Apoptosis related,Aurora Kinase,Autophagy,FLT3,JNK,Serine/threonin kinase,Trk receptor
Pathway:MAPK
Information:SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. SP600125 inhibits autophagy and activates apoptosis.
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