Name:Tigecycline (GAR-936)
Synonyms:Tygacil, GAR-936, WAY-GAR-936, TBG-MINO
CAS Number:220620-09-7
Formula:C29H39N5O8
M.w.:585.65
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:170.75
Form:free base
SMILES:CN(C)C1C2CC3CC4=C(C(=C(NC(=O)CNC(C)(C)C)C=C4N(C)C)O)C(=O)C3=C(O)C2(O)C(=O)C(=C1O)C(N)=O
ALogP:-0.381
Target:Antineoplastic and Immunosuppressive Antibiotics,Autophagy,Bacterial
Pathway:Microbiology
Information:Tigecycline (Tygacil, GAR-936, WAY-GAR-936, TBG-MINO) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.
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