Name:Rigosertib (ON-01910)
Synonyms:N/A
CAS Number:1225497-78-8
Formula:C21H24NNaO8S
M.w.:473.47
DMSO (mg/mL)Max Solubility:95
DMSO (mM)Max Solubility:200.65
Form:Sodium Salt
SMILES:[Na+].COC1=CC(=C(\C=C\[S](=O)(=O)CC2=CC=C(OC)C(=C2)NCC([O-])=O)C(=C1)OC)OC
ALogP:0.632
Target:Akt,Apoptosis related,PI3K,PLK
Pathway:Cell Cycle
Information:Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3.
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