Name:Ivermectin (MK-933)
Synonyms:MK-933
CAS Number:70288-86-7
Formula:C48H74O14
M.w.:875.09
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:114.27
Form:Free Base
SMILES:CCC(C)C1OC2(CCC1C)CC3CC(C\C=C(C)\C(OC4CC(OC)C(OC5CC(OC)C(O)C(C)O5)C(C)O4)C(C)\C=C\C=C\6COC7C(O)C(=CC(C(=O)O3)C67O)C)O2
ALogP:4.743
Target:AChR,Autophagy,Chloride Channel,COVID-19,HIV,Mitophagy,P2 Receptor
Pathway:Transmembrane Transporters
Information:Ivermectin (MK-933, IVM) is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. Ivermectin (MK-933, IVM) is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). Ivermectin has potent antiviral activity towards both HIV-1 and dengue virus. Ivermectin induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
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