Name:Dexamethasone (MK-125)
Synonyms:NSC 34521, Hexadecadrol, Prednisolone F,MK-125
CAS Number:50-02-2
Formula:C22H29FO5
M.w.:392.46
DMSO (mg/mL)Max Solubility:79
DMSO (mM)Max Solubility:201.29
Form:free base
SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO
ALogP:1.708
Target:Autophagy,Complement System,COVID-19,Glucocorticoid Receptor,IL Receptor,Mitophagy
Pathway:Immunology & Inflammation
Information:Dexamethasone (MK-125, NSC 34521, Hexadecadrol, Prednisolone F) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.
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