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「同位素标记抑制剂」Orphenadrine-d3 citrate

作者:瑞禧生物 发布时间:2025-07-07 09:39:41 次浏览

生物活性:Orphenadrine-d3 (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.
IC50 & Target:NMDA Receptor
体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Orphenadrine-d3 citrate 相关抗体:
PSD95 Antibody
NMDAR1 Antibody
NMDAR2A Antibody
Ionotropic Glutamate Receptor 2 Antibody (YA1143)
GRM5 Antibody (YA1509)
Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)
NR2E1 Antibody (YA2648)
NR2F2 Antibody (YA1223)
KA1 Antibody (YA1879)
GRIK2 Antibody (YA2705)
PSD93 Antibody (YA3187)
分子量:464.52
Formula:C24H28D3NO8
非标记 CAS:4682-36-4
中文名称:奥芬那君 d3 (柠檬酸盐)
运输条件:Room temperature in continental US; may vary elsewhere.
储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (529 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Kornhuber, J., et al., Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect, 1995. 102(3): p. 237-46.
 [Content Brief]
[3]. Pubill, D., et al., Assessment of the adrenergic effects of orphenadrine in rat vas deferens. J Pharm Pharmacol, 1999. 51(3): p. 307-12.
 [Content Brief]