生物活性：Buformin-d9 (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Buformin-d9 hydrochloride 相关抗体:
AMPK alpha Antibody
Phospho-AMPK alpha 2 (Thr172) Antibody
AMPK alpha 2 Antibody (YA833)
Phospho-AMPK alpha 2(Ser345) Antibody
AMPK alpha 1 Antibody
AMPK alpha 1 Antibody (YA624)
Phospho-AMPK alpha 1 (Ser496) Antibody (YA226)
Phospho-Hormone sensitive lipase (Ser853) Antibody
ATF4 Antibody (YA605)
AMPK alpha 2 Antibody (YA623)
AMPK beta 1 Antibody
AMPK gamma 1 Antibody
ATF4 Antibody
Phospho-AMPK alpha 1 (Ser496) Antibody
MARK2 Antibody (YA2104)
MARK3 Antibody (YA2150)
Phospho-Hormone Sensitive Lipase (Ser855) Antibody (YA2599)
分子量：202.73
Formula：C6H7D9ClN5
非标记 CAS：692-13-7
中文名称：丁双胍盐酸盐-d9；1-丁基双胍盐酸盐-d9；丁福明盐酸盐-d9；丁二胍盐酸盐-d9
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (530 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Amanda B Parris, et al. Buformin Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res
 [Content Brief]
[3]. Jing Li, et al. Buformin Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517.
 [Content Brief]