生物活性：TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
TML-6-d3 相关抗体:
PGK1 Antibody
NF-KB p65 Antibody
Phospho-NF-KB p65 (Ser536) Antibody
Phospho-NF-κB p65 (Ser529) Antibody
NF-KB p65 Antibody (YA267)
Keap1 Antibody
Phospho-mTOR (Ser2448) Antibody (YA171)
Phospho-Nrf2 (Ser40) Antibody (YA169)
mTOR Antibody (YA281)
NF-KB p105/p50 Antibody
RelB Antibody
Ret Antibody
Retinoic Acid Receptor alpha Antibody
RHEB Antibody
SOD2 Antibody (YA071)
SOX1 Antibody
TRAF2 Antibody
Phospho-mTOR (Ser2448) Antibody (YA691)
Phospho-Nrf2 (Ser40) Antibody (YA168)
Hamartin Antibody
4E BP1 Antibody
Annexin A1 Antibody (YA832)
DDX3 Antibody (YA784)
mTOR Antibody
NF-KB p100 Antibody
NF-KB p105 Antibody (YA700)
Nrf1 Antibody
Phospho-4E BP1 (Thr46) Antibody
Phospho-mTOR (Ser2481) Antibody
Phospho-NF-KB p65 (Thr254) Antibody
分子量：526.64
Formula：C30H34D3NO7
CAS 号：2673270-28-3
非标记 CAS：1462868-88-7
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21(15):5459.
 [Content Brief]