生物活性：CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI)[1].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
CX516-d10 相关抗体:
PSD95 Antibody
NMDAR1 Antibody
NMDAR2A Antibody
Ionotropic Glutamate Receptor 2 Antibody (YA1143)
GRM5 Antibody (YA1509)
Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Antibody (YA2081)
NR2E1 Antibody (YA2648)
NR2F2 Antibody (YA1223)
KA1 Antibody (YA1879)
GRIK2 Antibody (YA2705)
PSD93 Antibody (YA3187)
分子量：251.35
Formula：C14H5D10N3O
CAS 号：1286653-21-1
非标记 CAS：154235-83-3
中文名称：安帕来斯 d10
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009 Nov;206(4):631-40.
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