生物活性：Glimepiride-d5 is the deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Glimepiride-d5 相关抗体:
RAGE Antibody
PMP70 Antibody (YA1628)
Amyloid Precursor Protein Antibody (YA1130)
Serum Amyloid A Antibody (YA1168)
DISC1 Antibody (YA2430)
Phospho-Amyloid Precursor Protein (Thr743) Antibody (YA2568)
APLP2 Antibody (YA2722)
LRRC15 Antibody (YA3182)
Mint3 Antibody (YA3242)
分子量：495.65
Formula：C24H29D5N4O5S
CAS 号：1028809-90-6
非标记 CAS：93479-97-1
中文名称：格列美脲 d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (524 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38(8): p. 1120-30.
 [Content Brief]
[3]. Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4.
 [Content Brief]
[4]. Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS). [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.
 [Content Brief]