生物活性：Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508)[1]. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[3]. Clarithromycin significantly inhibits the HERG potassium current[4].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[5].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Clarithromycin-d3 相关抗体:
Cytochrome C Antibody
Cytochrome P450 17A1 Antibody
Aromatase Antibody
MRP2 Antibody
CYP11A1 Antibody
Elongation factor 2 Antibody (YA962)
Elongation factor 2 Antibody (YA964)
PU.1/SPI1 Antibody (YA1116)
Cytochrome P450 1B1 Antibody (YA1836)
Adrenodoxin Antibody (YA2005)
Cytochrome P450 27A1 Antibody (YA2163)
Cytochrome P450 2C9 Antibody (YA2166)
Cytochrome P450 2E1 Antibody (YA2302)
Cytochrome P450 Reductase Antibody (YA2619)
Thromboxane A Synthase Antibody (YA2670)
Cytochrome P450 3A4 Antibody (YA3365)
HSD11B1 Antibody (YA3376)
Cytochrome P450 17A1 Antibody (YA786)
Sulfadimidine Antibody (YA906)
CYP2E1 Antibody
CYP1A2 Antibody
Elongation factor 2 Antibody (YA963)
Anthrax Protective gen Antibody (YA1060)
PLSCR3 Antibody (YA1672)
PROX1 Antibody (YA1754)
Elongation factor 1 gamma Antibody (YA2004)
Cytochrome P450 4A Antibody (YA2087)
Pulmonary Surfactant Associated Protein D Antibody (YA2107)
Cytochrome P450 24A1 Antibody (YA2121)
Cytochrome P450 26A1 Antibody (YA2259)
分子量：750.97
Formula：C38H66D3NO13
CAS 号：959119-22-3
非标记 CAS：81103-11-9
性状：固体
颜色：White to off-white
中文名称：克拉霉素-d3；克拉红霉素-d3；6-0-甲基红霉素A-d3；6氧甲基红霉素-d3；甲红霉素-d3；甲氧基红霉素-d3；克红霉素-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)