生物活性：Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].
IC50 & Target[1]：Cdk4/cyclin D3
9 nM (IC50)
Cdk4/cyclin D1
11 nM (IC50)
Cdk6/cyclin D2
16 nM (IC50)
DYRK1A
2000 nM (IC50)
MAPK
8000 nM (IC50)
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Palbociclib-d8 相关抗体:
Cyclin E1 Antibody (YA483)
CD133 Antibody
Cdk2 Antibody
Cdk4 Antibody
Cdk5 Antibody
Cdk6 Antibody
Cyclin D3 Antibody
Cdk7 Antibody
CDK16 Antibody
CDK5 Antibody (YA796)
CDK9 Antibody
CDKN2A/p16INK4a Antibody (YA508)
Phospho-CDK1 (Tyr15) Antibody
Phospho-CDK1/2/3 (Thr14) Antibody
Phospho-CDK2 (Tyr15) Antibody
Phospho-Cyclin B1 (Ser126) Antibody
CDKN2A/p16INK4a Antibody
CDKN2C Antibody
Phospho-CDC6 (Ser54) Antibody (YA1017)
Cyclin E2 Antibody (YA2594)
CDC25C Antibody (YA2624)
CDC6 Antibody (YA2626)
CDC40 Antibody (YA3168)
Cyclin A1/A2 Antibody (YA3336)
CRK Antibody (YA790)
Cyclin H Antibody (YA788)
Cyclin H Antibody
Phospho-CDC6 (Ser106) Antibody (YA1016)
CDC7 Antibody (YA1152)
Cyclin D3/CCND3 Antibody (YA1201)
分子量：455.58
Formula：C24H21D8N7O2
CAS 号：1628752-83-9
非标记 CAS：571190-30-2
性状：固体
颜色：Light yellow to yellow
中文名称：帕布昔利布 d8
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month