生物活性：Ceftiofur-d3 sodium is deuterium labeled Ceftiofur sodium (HY-B0898). Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3][4].
IC50 & Target：β-lactam
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Ceftiofur-d3 sodium 相关抗体:
IL-1 beta Antibody
NF-KB p65 Antibody
Phospho-NF-KB p65 (Ser536) Antibody
TNF alpha Antibody
Phospho-NF-κB p65 (Ser529) Antibody
NF-KB p65 Antibody (YA267)
p38 Antibody
Phospho-p38 (Thr180/Tyr182) Antibody
TNF Receptor 2 Antibody
ASK1 Antibody (YA609)
CD40 Antibody
CD40L Antibody
DR5 Antibody
EpCAM Antibody (YA772)
MAPK14 Antibody
NF-KB p105/p50 Antibody
RelB Antibody
Ret Antibody
Retinoic Acid Receptor alpha Antibody
SOD2 Antibody (YA071)
SOX1 Antibody
TRAF2 Antibody
IL-1 beta Antibody (YA345)
Annexin A1 Antibody (YA832)
ATF2 Antibody
CD127 Antibody
DDX3 Antibody (YA784)
EpCAM Antibody (YA458)
IL-18 Antibody
IL-4 Antibody (YA343)
分子量：548.56
Formula：C19H13D3N5NaO7S3
非标记 CAS：104010-37-9
中文名称：头孢噻呋钠-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-236.
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[2]. Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8(3):332-6.
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[3]. Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372(1):73-7.
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[4]. Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31(6):422-7.
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