生物活性：Podofilox-d6 is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Podofilox-d6 相关抗体:
alpha Tubulin Antibody
LC3A/B Antibody
Beta Tubulin Antibody
beta Tubulin Antibody (YA839)
Doublecortin Antibody
LC3B Antibody (YA308)
Stathmin 1 Antibody (YA049)
Stathmin 1 Antibody (YA050)
alpha Tubulin (acetyl K40) Antibody
beta III Tubulin Antibody
gamma Tubulin Antibody
LC3B Antibody
Beta Tubulin Antibody (HRP) (YA865)
Cytokeratin 5 Antibody
MAP2 Antibody
DM1 Antibody (YA898)
CK18 Antibody
Cytokeratin 19 Antibody
Cytokeratin 7 Antibody (YA951)
Cytokeratin 15 Antibody (YA1493)
p63 Antibody (YA1531)
Cytokeratin 6 Antibody (YA1701)
Cytokeratin 4 Antibody (YA1762)
Cytokeratin 10 Antibody (YA1857)
Cytokeratin 14 Antibody (YA1876)
Cytokeratin 1 Antibody (YA2665)
Stanniocalcin 1 Antibody (YA2690)
Cytokeratin 13 Antibody (YA2695)
HRH3 Antibody (YA2701)
Phospho-alpha Tubulin (Tyr272) Antibody (YA3041)
分子量：420.44
Formula：C22H16D6O8
非标记 CAS：518-28-5
中文名称：依托泊苷EP杂质M-d6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Wang B, Chen L, Zhen H, et al. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41(1):163-75.
 [Content Brief]
[3]. Guerrero E, Abad A, Montenegro G, et al. Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. Pharm Biol. 2013 Jan 31.
 [Content Brief]
[4]. Li M, Zhou L, Yang D, et al. Biochemical composition and antioxidant capacity of extracts from Podophyllum hexandrum rhizome. BMC Complement Altern Med. 2012 Dec 22;12:263.
 [Content Brief]
[5]. Prasad V, Chaudhuri AR, Curcio M, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998 Oct;17(7):663-8.
 [Content Brief]
[6]. Podophyllotoxin