生物活性：DM4-d6 is deuterium labeled DM4. DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
DM4-d6 相关抗体:
alpha Tubulin Antibody
LC3A/B Antibody
Beta Tubulin Antibody
beta Tubulin Antibody (YA839)
Doublecortin Antibody
LC3B Antibody (YA308)
Stathmin 1 Antibody (YA049)
Stathmin 1 Antibody (YA050)
alpha Tubulin (acetyl K40) Antibody
beta III Tubulin Antibody
gamma Tubulin Antibody
LC3B Antibody
Beta Tubulin Antibody (HRP) (YA865)
Cytokeratin 5 Antibody
MAP2 Antibody
DM1 Antibody (YA898)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
CK18 Antibody
Cytokeratin 19 Antibody
Cytokeratin 7 Antibody (YA951)
Cytokeratin 15 Antibody (YA1493)
p63 Antibody (YA1531)
Cytokeratin 6 Antibody (YA1701)
Cytokeratin 4 Antibody (YA1762)
Cytokeratin 10 Antibody (YA1857)
Cytokeratin 14 Antibody (YA1876)
Cytokeratin 1 Antibody (YA2665)
Stanniocalcin 1 Antibody (YA2690)
Cytokeratin 13 Antibody (YA2695)
分子量：786.40
Formula：C38H48D6ClN3O10S
非标记 CAS：796073-69-3
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
纯度 & 产品资料
纯度： 99.11%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
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