生物活性：Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Valproic acid-d14 sodium 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
GAPDH Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
HDAC1 Antibody
HDAC6 Antibody
METTL3 Antibody
HDAC4 Antibody (YA741)
TSG101 Antibody
SATB2 Antibody
Alkaline Phosphatase Antibody
Calnexin Antibody (YA573)
CD4 Antibody
HDAC10 Antibody
HDAC2 Antibody
HDAC3 Antibody
HDAC4 Antibody
Jagged1 Antibody
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
NUMB Antibody
OPA1 Antibody
RBM3 Antibody
Synaptophysin Antibody (YA043)
分子量：180.28
Formula：C8HD14NaO2
非标记 CAS：1069-66-5
性状：固体
颜色：White to off-white
中文名称：丙戊酸钠-d14；丙戊酸钠盐-d14；定百痉-d14；癫扑净-d14；抗癫灵-d14；敌白痉-d14；2-丙基戊酸钠-d14
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
纯度 & 产品资料
纯度： 96.45%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005.
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[3]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.
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[4]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.
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[5]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50.
 [Content Brief]
[6]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10.
 [Content Brief]
[7]. Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7.
 [Content Brief]