生物活性：Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib (HY-114277). Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC)[1][2][3].
IC50 & Target：KRAS(G12C)
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Sotorasib-d7 相关抗体:
Rab5 Antibody
RAB8A Antibody
Epac1 Antibody
GRB2 Antibody
RAB7 Antibody
Ras Antibody
RASA1 Antibody
RhoA Antibody (YA093)
RhoA Antibody
RhoA/B/C Antibody
Rab10 Antibody (YA1789)
Rab7B Antibody (YA1798)
Rab9 Antibody (YA1800)
GTPase NRAS Antibody (YA1830)
GTPase HRAS Antibody (YA1833)
Rab4 Antibody (YA2272)
IQGAP1 Antibody (YA2388)
G3BP Antibody (YA2432)
GPRC5B Antibody (YA2964)
Rab11A Antibody (YA2976)
Rac Antibody (YA3290)
SOS1 Antibody (YA3313)
CDC42EP1 Antibody
RAB5C Antibody
GRB2 Antibody (YA748)
Rab22A Antibody (YA1791)
Rab45 Antibody (YA1792)
Rac3 Antibody (YA1802)
RALB Antibody (YA1816)
Rab25 Antibody (YA1881)
分子量：567.64
Formula：C30H23D7F2N6O3
非标记 CAS：2296729-00-3
性状：固体
颜色：White to off-white
中文名称：索托拉西布-d7
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)