生物活性：MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
IC50 & Target：Auristatin
体外研究(In Vitro)：MMAF 对一组细胞系表现出体外细胞毒性。Karpas 299、H3396、786-O 和 Caki-1 的 IC50 值分别为 119、105、257 和 200 nM。靶向 MMAF 比游离药物更有效，MMAF 的 cAC10 偶联物显示出显著的活性。在摩尔基础上，cAC10-L1-MMAF4 的效力平均比游离 MMAF 强 2200 多倍，并且对所有测试的 CD30 阳性细胞系均有活性[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
MMAF-d8 hydrochloride 相关抗体:
alpha Tubulin Antibody
LC3A/B Antibody
Beta Tubulin Antibody
beta Tubulin Antibody (YA839)
Doublecortin Antibody
LC3B Antibody (YA308)
Stathmin 1 Antibody (YA049)
Stathmin 1 Antibody (YA050)
alpha Tubulin (acetyl K40) Antibody
beta III Tubulin Antibody
gamma Tubulin Antibody
LC3B Antibody
Beta Tubulin Antibody (HRP) (YA865)
Cytokeratin 5 Antibody
MAP2 Antibody
DM1 Antibody (YA898)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
CK18 Antibody
Cytokeratin 19 Antibody
Cytokeratin 7 Antibody (YA951)
Cytokeratin 15 Antibody (YA1493)
p63 Antibody (YA1531)
Cytokeratin 6 Antibody (YA1701)
Cytokeratin 4 Antibody (YA1762)
Cytokeratin 10 Antibody (YA1857)
Cytokeratin 14 Antibody (YA1876)
Cytokeratin 1 Antibody (YA2665)
Stanniocalcin 1 Antibody (YA2690)
Cytokeratin 13 Antibody (YA2695)
体内研究(In Vivo)
小鼠对 MMAF 的最大耐受剂量 (>16 mg/kg) 远高于 MMAE (1 mg/kg)。cAC10-L1-MMAF4 在小鼠中的 MTD 为 50 mg/kg，在大鼠中为 15 mg/kg。相应的cAC10-L4-MMAF4 ADC毒性更小，小鼠和大鼠的 MTD 分别大于150 mg/kg 和 90 mg/kg[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：776.47
Formula：C39H58D8ClN5O8
非标记 CAS：1415246-68-2
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。