生物活性：Dxd-d5 is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1].
IC50 & Target：Topoisomerase I
0.31 μM (IC50)
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Dxd-d5 相关抗体:
TOP2A Antibody
DXd Antibody (YA897)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
SN38 Antibody (YA923)
Topoisomerase I Antibody (YA2237)
分子量：498.51
Formula：C26H19D5FN3O6
非标记 CAS：1599440-33-1
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)