生物活性：Manidipine-d4 is the deuterium labeled Manidipine (HY-B0419). Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy[1][2][3][4][5][6][7][8].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Manidipine-d4 相关抗体:
Annexin VI Antibody
IL-1 beta Antibody
Calbindin Antibody
Calreticulin Antibody
EpCAM Antibody (YA772)
IL-1 beta Antibody (YA345)
CD127 Antibody
EpCAM Antibody (YA458)
IL-18 Antibody
IL-4 Antibody (YA343)
IL-6 Antibody
SOCS1 Antibody
IL-8/CXCL8 Antibody
IL-10 Antibody
IL17A Antibody
IL-1 alpha Antibody
Cardiac Troponin I/TNNC1 Antibody
SCGN Antibody (YA1167)
IL-6R Antibody
IL-13 Receptor alpha 1 Antibody (YA1624)
RAMP1 Antibody (YA1818)
Annexin V Antibody (YA1829)
Striatin 4 Antibody (YA2088)
Fibulin 5 Antibody (YA2448)
RASGRP1 Antibody (YA2546)
IL-12 beta Antibody (YA2753)
Fibulin 1 Antibody (YA2831)
EFEMP1 Antibody (YA2883)
IL-32 Antibody (YA2911)
IL-11 Receptor alpha Antibody (YA3092)
分子量：614.72
Formula：C35H34D4N4O6
CAS 号：1189656-59-4
非标记 CAS：89226-50-6
中文名称：马尼地平-d4；美尼地平-d4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Roth M, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4071-5.
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[2]. Huang S, et al. Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells. Am Heart J. 1993 Feb;125(2 Pt 2):589-97.
 [Content Brief]
[3]. Costa S, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70.
 [Content Brief]
[4]. Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn Circ J. 1998 Jan;62(1):47-52.
 [Content Brief]
[5]. Tojo A, et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Dec;20(6):895-9.
 [Content Brief]
[6]. Rossoni G, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587(1-3):224-30.
 [Content Brief]
[7]. Haraguchi K, et al. Catalepsy induced by manidipine, a calcium channel blocker, in mice. J Pharm Pharmacol. 1996 Apr;48(4):429-32.
 [Content Brief]
[8]. Souza C N S, et al. 074—(SOA0068) Anticonvulsant activity of acute treatment with manidipine in pentylenetetrazole-and pilocarpine-induced seizure models in mice. Epilepsy & Behavior, 2014, 38: 214.