生物活性：Lovastatin-d3 hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Lovastatin-d3 hydroxy acid sodium 相关抗体:
HMGCS2 Antibody
HMGB1 Antibody
HMGCR Antibody
Baf180 Antibody (YA1176)
BANF1 Antibody (YA1740)
LEF1 Antibody (YA3164)
HMGA1 Antibody (YA1185)
HMGA2 Antibody (YA1186)
Baf57 Antibody (YA2110)
HMGN2 Antibody (YA2839)
HMG4 Antibody (YA2992)
HMGB2 Antibody (YA2995)
HMGCL Antibody (YA3024)
分子量：447.56
Formula：C24H35D3NaO6
CAS 号：1217528-38-5
非标记 CAS：75225-50-2
中文名称：洛伐他汀EP杂质B Sodium Salt (Lovastatin Hydroxy Acid Sodium Salt)-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (525 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.
 [Content Brief]