生物活性：AICAR-13C2,15N (Acadesine-13C2,15N; AICA Riboside-13C2,15N) is the 13C and 15N labeled AICAR (HY-13417)[1]. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor[2][3].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
瑞禧生物 has not independently confirmed the accuracy of these methods. They are for reference only.
AICAR-13C2,15N 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
GAPDH Antibody
YAP1 Antibody
AMPK alpha Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
Phospho-AMPK alpha 2 (Thr172) Antibody
Phospho-YAP1 (Ser127) Antibody (YA136)
METTL3 Antibody
AMPK alpha 2 Antibody (YA833)
Phospho-AMPK alpha 2(Ser345) Antibody
AMPK alpha 1 Antibody
TSG101 Antibody
Alkaline Phosphatase Antibody
Calnexin Antibody (YA573)
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
OPA1 Antibody
RBM3 Antibody
Synaptophysin Antibody (YA043)
AMPK alpha 1 Antibody (YA624)
Laminin beta 1 Antibody
Phospho-AMPK alpha 1 (Ser496) Antibody (YA226)
Phospho-Hormone sensitive lipase (Ser853) Antibody
分子量：261.21
Formula：C713C2H14N315NO5
CAS 号：1609374-70-0
非标记 CAS：2627-69-2
中文名称：阿卡地新-13C2,15N
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (541 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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